Streptomyces has been shown to be an invaluable host for the secretory production of biopharmaceuticals and other heterologous proteins. Streptomics aims to further evaluate this host as a cell factory for the industrial production of proteins of diverse origin including from mammalians, bacteria and archeae of interest for human health and environment. To enhance production, Streptomics will combine genomic data, metabolic network modelling, metabolic flux analysis and proteomics. This systems biology approach will identify genes/proteins with key roles in protein secretion and their interrelationship with cell growth, secretion stress control and energy production/consumption. Successful realisation of the objectives of the project will therefore provide useful and commercially valuable innovation to the EU Streptomyces protein production platform.